abstract：BACKGROUND:Sex differences in obesity and related diseases are well established. Gonadal hormones are a major determinant of these sex differences. However, sex differences in body size and composition are evident prior to exposure to gonadal hormones, providing evidence for gonadal-independent contributions attributab...

journal_title：Molecular metabolism

authors： Zore T,Palafox M,Reue K

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:In addition to their crucial role in reproduction, estrogens are key regulators of energy and glucose homeostasis and they also exert several cardiovascular protective effects. These beneficial actions are mainly mediated by estrogen receptor alpha (ERα), which is widely expressed in metabolic and vascular t...

journal_title：Molecular metabolism

authors： Gourdy P,Guillaume M,Fontaine C,Adlanmerini M,Montagner A,Laurell H,Lenfant F,Arnal JF

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex tra...

journal_title：Molecular metabolism

authors： Panzeri I,Pospisilik JA

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:N-acylethanolamines play different roles in energy balance; anandamide (AEA) stimulates energy intake and storage, N-palmitoylethanolamide (PEA) counters inflammation, and N-oleoylethanolamide (OEA) mediates anorectic signals and lipid oxidation. Inconsistencies in the association of plasma N-acylethanolamine...

journal_title：Molecular metabolism

authors： Fanelli F,Mezzullo M,Repaci A,Belluomo I,Ibarra Gasparini D,Di Dalmazi G,Mastroroberto M,Vicennati V,Gambineri A,Morselli-Labate AM,Pasquali R,Pagotto U

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer defined by robust lipid accumulation, which prior studies have indicated plays an important role in tumor progression. We hypothesized that the peroxisome proliferator-activated receptor gamma (PPARγ), detected in both ccRCC tumors and cell...

journal_title：Molecular metabolism

authors： Sanchez DJ,Steger DJ,Skuli N,Bansal A,Simon MC

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within adipocytes rather than oxidizing it, and thus ultimately gain weight. The 'overflow hypothesis' ...

journal_title：Molecular metabolism

authors： Girousse A,Virtue S,Hart D,Vidal-Puig A,Murgatroyd PR,Mouisel E,Sengenès C,Savage DB

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) regulate food intake and body weight, glucose metabolism and convey the reward value of sucrose. In this report, we set out to establish the respective roles of MCH and conventional neurotransmitters in these neurons. METHODS:MCH n...

journal_title：Molecular metabolism

authors： Schneeberger M,Tan K,Nectow AR,Parolari L,Caglar C,Azevedo E,Li Z,Domingos A,Friedman JM

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Mitochondrial pyruvate dehydrogenase kinases 1-4 (PDKs1-4) negatively regulate activity of the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDKs play a pivotal role in maintaining energy homeostasis and contribute to metabolic flexibility by attenuating PDC activity in various mammalian...

journal_title：Molecular metabolism

authors： Wu CY,Tso SC,Chuang JL,Gui WJ,Lou M,Sharma G,Khemtong C,Qi X,Wynn RM,Chuang DT

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 (GLP-1) neurons in the hindbrain densely innervate the dorsomedial hypothalamus (DMH), a nucleus strongly implicated in body weight regulation and the sympathetic control of brown adipose tissue (BAT) thermogenesis. Therefore, DMH GLP-1 receptors (GLP-1R) are well placed to regulate en...

journal_title：Molecular metabolism

authors： Lee SJ,Sanchez-Watts G,Krieger JP,Pignalosa A,Norell PN,Cortella A,Pettersen KG,Vrdoljak D,Hayes MR,Kanoski SE,Langhans W,Watts AG

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:GPR142 agonists are being pursued as novel diabetes therapies by virtue of their insulin secretagogue effects. But it is undetermined whether GPR142's functions in pancreatic islets are limited to regulating insulin secretion. The current study expands research on its action. METHODS AND RESULTS:We demonstra...

journal_title：Molecular metabolism

authors： Lin HV,Wang J,Wang J,Li W,Wang X,Alston JT,Thomas MK,Briere DA,Syed SK,Efanov AM

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Mutations to the BSCL2 gene disrupt the protein seipin and cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals exhibit a near complete loss of white adipose tissue (WAT) and suffer from metabolic disease. Seipin is critical for adipocyte development in culture and mi...

journal_title：Molecular metabolism

authors： Mcilroy GD,Suchacki K,Roelofs AJ,Yang W,Fu Y,Bai B,Wallace RJ,De Bari C,Cawthorn WP,Han W,Delibegović M,Rochford JJ

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). ...

journal_title：Molecular metabolism

authors： Tran KV,Fitzgibbons T,Min SY,DeSouza T,Corvera S

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Recent reports have implicated the p53 tumor suppressor in the regulation of lipid metabolism. We hypothesized that the pharmacological activation of p53 with low-dose doxorubicin, which is widely used to treat several types of cancer, may have beneficial effects on nonalcoholic fatty liver disease (NAFLD) an...

journal_title：Molecular metabolism

authors： Porteiro B,Fondevila MF,Buque X,Gonzalez-Rellan MJ,Fernandez U,Mora A,Beiroa D,Senra A,Gallego R,Fernø J,López M,Sabio G,Dieguez C,Aspichueta P,Nogueiras R

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and energy metabolism. Genome-wide association studies identified significant associations between body mass index (BMI) and multiple loci near Cell adhesion...

journal_title：Molecular metabolism

authors： Yan X,Wang Z,Schmidt V,Gauert A,Willnow TE,Heinig M,Poy MN

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:The cocaine- and amphetamine-regulated transcript (CART) codes for a pivotal neuropeptide important in the control of appetite and energy homeostasis. However, limited understanding exists for the defined effector sites underlying CART function, as discrepant effects of central CART administration have been r...

journal_title：Molecular metabolism

authors： Lau J,Farzi A,Qi Y,Heilbronn R,Mietzsch M,Shi YC,Herzog H

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Leptin is a cytokine produced by adipose tissue that acts mainly on the hypothalamus to regulate appetite and energy homeostasis. Previous studies revealed that the leptin receptor is expressed not only in neurons, but also in glial cells. Microglia are resident immune cells in the brain that play an essentia...

journal_title：Molecular metabolism

authors： Gao Y,Vidal-Itriago A,Milanova I,Korpel NL,Kalsbeek MJ,Tom RZ,Kalsbeek A,Hofmann SM,Yi CX

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Brown adipose tissue (BAT) thermogenesis depends on the mobilization and oxidation of fatty acids from intracellular lipid droplets (LD) within brown adipocytes (BAs); however, the identity and function of LD proteins that control BAT lipolysis remain incomplete. Proteomic analysis of mouse BAT subcellular fr...

journal_title：Molecular metabolism

authors： Ramseyer VD,Kimler VA,Granneman JG

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that skeletal muscle of endurance-trained male runners would exhibit elevated autophagy and mitophagy markers, which would be associated with greater metabolic flexibility following a high-fat meal (HFM). METHODS:Muscle biopsies were collected to determine differences in autophagy an...

journal_title：Molecular metabolism

authors： Tarpey MD,Davy KP,McMillan RP,Bowser SM,Halliday TM,Boutagy NE,Davy BM,Frisard MI,Hulver MW

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Besides functioning as an intracellular metabolite, succinate acts as a stress-induced extracellular signal through activation of GPR91 (SUCNR1) for which we lack suitable pharmacological tools. METHODS AND RESULTS:Here we first determined that the cis conformation of the succinate backbone is preferred and ...

journal_title：Molecular metabolism

authors： Trauelsen M,Rexen Ulven E,Hjorth SA,Brvar M,Monaco C,Frimurer TM,Schwartz TW

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal muscle are limited. Therefore, the present study aimed to identify novel mi...

journal_title：Molecular metabolism

authors： Dahlmans D,Houzelle A,Andreux P,Jörgensen JA,Wang X,de Windt LJ,Schrauwen P,Auwerx J,Hoeks J

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:In the adult brain, neural stem cells (NSCs) located in the subventricular zone (SVZ) produce both neuronal and glial cells. Thyroid hormones (THs) regulate adult NSC differentiation towards a neuronal phenotype, but also have major roles in mitochondrial metabolism. As NSC metabolism relies mainly on glycoly...

journal_title：Molecular metabolism

authors： Gothié JD,Sébillot A,Luongo C,Legendre M,Nguyen Van C,Le Blay K,Perret-Jeanneret M,Remaud S,Demeneix BA

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE AND METHODS:Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. RESULTS:While mice lacking sensory neurons displayed no differe...

journal_title：Molecular metabolism

authors： Udit S,Burton M,Rutkowski JM,Lee S,Bookout AL,Scherer PE,Elmquist JK,Gautron L

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Previous work has suggested that white adipocytes may also show a mammary luminal secretory cell phenotype during lactation. The capacity of brown and beige/brite adipocytes to display a mammary cell phenotype and the levels at which they demonstrate such phenotypes in vivo is currently unknown. METHODS:To i...

journal_title：Molecular metabolism

authors： Li L,Li B,Li M,Niu C,Wang G,Li T,Król E,Jin W,Speakman JR

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Functional investigation of novel gene/protein targets associated with adipocyte differentiation or function heavily relies on efficient and accessible tools to manipulate gene expression in adipocytes in vitro. Recent advances in gene-editing technologies such as CRISPR-Cas9 have not only eased gene editing ...

journal_title：Molecular metabolism

authors： Lundh M,Pluciñska K,Isidor MS,Petersen PSS,Emanuelli B

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Plasma insulin levels are predominantly the product of the morphological mass of insulin producing beta cells in the pancreatic islets of Langerhans and the functional status of each of these beta cells. Thus, deficiency in either beta cell mass or function, or both, can lead to insufficient levels of insuli...

journal_title：Molecular metabolism

authors： Chen C,Cohrs CM,Stertmann J,Bozsak R,Speier S

更新日期：2017-07-08 00:00:00

abstract：OBJECTIVE:Brown and white adipose tissue exerts pleiotropic effects on systemic energy metabolism in part by releasing endocrine factors. Neuregulin 4 (Nrg4) was recently identified as a brown fat-enriched secreted factor that ameliorates diet-induced metabolic disorders, including insulin resistance and hepatic steato...

journal_title：Molecular metabolism

authors： Chen Z,Wang GX,Ma SL,Jung DY,Ha H,Altamimi T,Zhao XY,Guo L,Zhang P,Hu CR,Cheng JX,Lopaschuk GD,Kim JK,Lin JD

更新日期：2017-06-21 00:00:00

abstract：OBJECTIVE:Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor (GLP1R) signal...

journal_title：Molecular metabolism

authors： Rozo AV,Babu DA,Suen PA,Groff DN,Seeley RJ,Simmons RA,Seale P,Ahima RS,Stoffers DA

更新日期：2017-05-15 00:00:00

abstract：OBJECTIVE:A significant portion of the heritable risk for complex metabolic disorders cannot be attributed to classic Mendelian genetic factors. At least some of this missing heritability is thought to be due to the epigenetic influence of parental and grandparental metabolic state on offspring health. Previous work su...

journal_title：Molecular metabolism

authors： Palu RAS,Praggastis SA,Thummel CS

更新日期：2017-04-26 00:00:00

abstract：OBJECTIVE:Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates metabolic homeostasis. Previous work has suggested that impairment of FGF21 signaling in adipose tissue may occur through downregulation of the obligate FGF21 co-receptor, β-klotho, which leads to "FGF21 resistance" during the onset of...

journal_title：Molecular metabolism

authors： Markan KR,Naber MC,Small SM,Peltekian L,Kessler RL,Potthoff MJ

更新日期：2017-03-27 00:00:00

abstract：OBJECTIVE:Identification of additional regulatory factors involved in the onset of obesity is important to understand the mechanisms underlying this prevailing disease and its associated metabolic disorders and to develop therapeutic strategies. Through isolation and analysis of a mutant, we aimed to uncover the functi...

journal_title：Molecular metabolism

authors： Zhu X,Xie S,Xu T,Wu X,Han M

更新日期：2017-03-18 00:00:00

abstract：OBJECTIVE:α-cells are the second most prominent cell type in pancreatic islets and are responsible for producing glucagon to increase plasma glucose levels in times of fasting. α-cell dysfunction and inappropriate glucagon secretion occur in both type 1 and type 2 diabetes. Thus, there is growing interest in studying b...

journal_title：Molecular metabolism

authors： Ackermann AM,Zhang J,Heller A,Briker A,Kaestner KH

更新日期：2017-01-12 00:00:00

abstract：BACKGROUND:GPRC6A, a widely expressed G-protein coupled receptor, is proposed to be a master regulator of complex endocrine networks and metabolic processes. GPRC6A is activated by multiple ligands, including osteocalcin (Ocn), testosterone (T), basic amino acids, and various cations. SCOPE OF REVIEW:We review the con...

journal_title：Molecular metabolism

authors： Pi M,Nishimoto SK,Quarles LD

更新日期：2016-12-21 00:00:00

abstract：OBJECTIVE/METHODS:DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter methylation along with mRNA profiles in paired samples of human subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from non-obese vs. obese individuals...

journal_title：Molecular metabolism

authors： Keller M,Hopp L,Liu X,Wohland T,Rohde K,Cancello R,Klös M,Bacos K,Kern M,Eichelmann F,Dietrich A,Schön MR,Gärtner D,Lohmann T,Dreßler M,Stumvoll M,Kovacs P,DiBlasio AM,Ling C,Binder H,Blüher M,Böttcher Y

更新日期：2016-11-16 00:00:00

abstract：OBJECTIVE:Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbiota remains unknown. METHODS:In a randomized within-subject crossover s...

journal_title：Molecular metabolism

authors： Benedict C,Vogel H,Jonas W,Woting A,Blaut M,Schürmann A,Cedernaes J

更新日期：2016-10-24 00:00:00

abstract：OBJECTIVE:Pharmacological activation of adenosine signaling has been shown to increase β-cell proliferation and thereby β-cell regeneration in zebrafish and rodent models of diabetes. However, whether adenosine has an endogenous role in regulating β-cell proliferation is unknown. The objective of this study was to dete...

journal_title：Molecular metabolism

authors： Schulz N,Liu KC,Charbord J,Mattsson CL,Tao L,Tworus D,Andersson O

更新日期：2016-09-20 00:00:00

abstract：OBJECTIVE:Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites. One concept of insulin secretion is that ATP citrate lyase generates short chain acyl-CoAs in the ...

journal_title：Molecular metabolism

authors： El Azzouny M,Longacre MJ,Ansari IH,Kennedy RT,Burant CF,MacDonald MJ

更新日期：2016-08-08 00:00:00

abstract：OBJECTIVE:A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-induced obese mice are resistant to achieving normoweight once the obesogenic conditions are reversed, in part because lowered circulating leptin leads to a reduction in metabolic rate and a rebound of hyperphagia that def...

journal_title：Molecular metabolism

authors： Chhabra KH,Adams JM,Jones GL,Yamashita M,Schlapschy M,Skerra A,Rubinstein M,Low MJ

更新日期：2016-08-05 00:00:00

abstract：OBJECTIVE:Metabolic challenges, such as a cold environment, stimulate sympathetic neural efferent activity to white adipose tissue (WAT) to drive lipolysis, thereby increasing the availability of free fatty acids as one source of fuel for brown adipose tissue (BAT) thermogenesis. WAT is also innervated by sensory nerve...

journal_title：Molecular metabolism

authors： Garretson JT,Szymanski LA,Schwartz GJ,Xue B,Ryu V,Bartness TJ

更新日期：2016-06-30 00:00:00

abstract：OBJECTIVE:The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve glucose tolerance in mice on chow or high-fat diet (HFD). METHODS:We tra...

journal_title：Molecular metabolism

authors： Arora T,Wegmann U,Bobhate A,Lee YS,Greiner TU,Drucker DJ,Narbad A,Bäckhed F

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Gut microbiota is considered as a major regulator of metabolic disease. This reconciles the notion of metabolic inflammation and the epidemic development of the disease. In addition to evidence showing that a specific gut microbiota characterizes patients with obesity, type 2 diabetes, and hepatic steatosis,...

journal_title：Molecular metabolism

authors： Burcelin R

更新日期：2016-06-06 00:00:00